SGOT / SGPT enzyme test

SGOT and SGPT are two enzymes found in the liver. SGOT / SGPT test is done to asses the state of the liver.

SGOT; serum glutamic oxaloacetic transaminase: Aspartate transaminase (AST)
SGPT; serum glutamic pyruvic transaminase: Alanine transaminase (ALT)

SGOT is basically a cytosolic enzyme where as SGPT is found in the mitochondria. Because of this mild and moderate liver damage gives high SGOT and normal SGPT (usually) value and sever liver damage gives high SGOT and SGPT test value. SGOT is also found in red blood cells and cardiac muscle, skeletal muscle, and kidney and brain tissue therefore damage and SGPT is found in cardiac and skeletal muscles therefore damage to these tissues can result in elevated SGOT/SGPT test value.

Normal SGOT/SGPT test value;

1. SGOT; Normal Adult Range: 0 - 48 U/L
2. SGPT; Normal Adult Range: 0 - 42 U/L

High SGOT/SGPT test values found in following conditions;

1. viral hepatitis
2. alcoholic liver diseases
3. non alcoholic liver disease
4. liver cell necrosis