Alcohol or ethanol is the major culprit of liver disease world wide. Amount of alcohol consume per day, type of alcohol, racial difference and genetic composition are some of the major factors which determine the severity and the course of the alcoholic liver disease.
Alcohol is mainly metabolized by the alcohol dehydrogenase system where as microsomal ethanol oxidizing system (MEOS) is responsible for the metabolism of small amount of alcohol. This MEOS system is induced by the regular alcohol consumption. End results of these metabolism pathways are largely responsible for the alcohol related organ damage.
Followings are the different stages of alcoholic liver disease;
1. Alcoholic fatty liver
2. Alcoholic hepatitis
3. Cirrhosis
Alcoholic fatty liver and alcoholic hepatitis are reversible if consumption is terminated. Cirrhosis is an irreversible condition and it carries poor prognosis.
Complications of alcoholic cirrhosis are:
1. Ascites
2. Portal hypertension
3. Variceal bleeding
4. Hepatic encephalopathy
5. Spontaneous bacterial peritonitis
6. Hepatorenal syndrome
7. Hepatocellular carcinoma
Alcohol is mainly metabolized by the alcohol dehydrogenase system where as microsomal ethanol oxidizing system (MEOS) is responsible for the metabolism of small amount of alcohol. This MEOS system is induced by the regular alcohol consumption. End results of these metabolism pathways are largely responsible for the alcohol related organ damage.
Followings are the different stages of alcoholic liver disease;
1. Alcoholic fatty liver
2. Alcoholic hepatitis
3. Cirrhosis
Alcoholic fatty liver and alcoholic hepatitis are reversible if consumption is terminated. Cirrhosis is an irreversible condition and it carries poor prognosis.
Complications of alcoholic cirrhosis are:
1. Ascites
2. Portal hypertension
3. Variceal bleeding
4. Hepatic encephalopathy
5. Spontaneous bacterial peritonitis
6. Hepatorenal syndrome
7. Hepatocellular carcinoma
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